Previous Topic Back Forward Next Topic
Print Page Frank Dieterle
 
Research TutorialsResearch Tutorials MetabonomicsMetabonomics Applications in Drug DevelopmentApplications in Drug Development Structure Elucidation of New BiomarkersStructure Elucidation of New Biomarkers Competitive StudyCompetitive Study
Home
News
About Me
Ph. D. Thesis
Publications
Research Tutorials
  Metabonomics
    Biology and "-omics"
    Definition of Metabonomics
    Methods
    Applications in Drug Development
      Possiblities and Examples
      Specific Biomarkers
      Patterns of Biomarkers
      Structure Elucidation of New Biomarkers
        Competitive Study
          Metabolite Enrichement
          HNBC 2D-NMR
          Biochemical Interpretation
        Ranking Study
    Acknowledgements
Downloads and Links
Contact
Search
Site Map
Print this Page Print this Page

Structure Elucidation - Competitive Study

In the competitive study, a structure elucidation of a new metabolite was performed. The data analysis could identify only one of the signals of the metabolite. The concentration levels of the metabolite were rather low and most of the signals could not be determined in the original samples. Therefore a special sample enrichement and separation and subsequent dedicated 2-D NMR experiments were necessary. The structure of this metabolite makes sense in terms of biochemical pathways and other significantly changed metabolites.

 

 

 

Page 186 © Frank Dieterle, 03.03.2019 Navigation